Mechanisms of Gasdermin Recognition by Proteases

Zhonghua Liu,Brianna M Busscher,Marta Storl-Desmond,Tsan Sam Xiao

Journal of Molecular Biology（2022）

引用 9|浏览21

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摘要

•Flexible linkers connect pore-forming NTDs with autoinhibitory CTDs in gasdermins.•Diverse proteases cleave gasdermin linkers or loops to regulate their activities.•Exosites strengthen enzyme-substrate interactions and enhance substrate selectivities.•Different features of gasdermin regulation by proteases underlie diverse functions.

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关键词

gasdermin,caspase,exosite,protease,cleavage

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