Etiology and outcomes of amputation in patients with peripheral artery disease in the EUCLID trial

Outcomes after amputation remain poor regardless of whether categorized as major or minor. The pattern of amputation drivers in PAD differs by history of DM with infection being the dominant etiology in those with DM and ischemia in those without DM. Greater focus is needed on the prognostic importance of minor amputation and of the multifactorial etiologies of amputation in PAD. Nomenclature with anatomical description of amputations and eliminating terms "major" or "minor" would seem appropriate.