An Enzyme-Free Cyclic Amplification Strategy for Intracellular Telomerase Activity Detection

Sensitive detection of telomerase and its inhibitor are of great significance to early diagnosis and treatment of malignant tumors. A cascade signal amplification strategy based on cyclic strand displacement reaction was designed to detect telomerase activity in cell lysates and living tumor cells. The primer can be elongated with repeated sequences of (TTAGGG)n due to the presence of t...