Zn2+-Dependent Peptide Nucleic Acid-Based Artificial Ribonucleases With Unprecedented Efficiency And Specificity

Olivia Luige,Partha Pratim Bose, Rouven Stulz,Peter Steunenberg, Omar Brun,Shalini Andersson,Merita Murtola,Roger Strömberg

CHEMICAL COMMUNICATIONS（2021）

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摘要

We present Zn2+-dependent dimethyl-dipyridophenazine PNA conjugates as efficient RNA cleaving artificial enzymes. These PNAzymes display site-specific RNA cleavage with 10 minute half-lives and cleave clinically relevant RNA models.

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