Ontological Modeling of Two-Component Regulatory Systems.

The two-component regulatory systems (TCSs), which comprise a sensor kinase and a response regulator, serve as a prevalent signal transduction system involving in multiple behaviors. To support systematic and interoperable representatoin of various types of TCS, we have initiated the development of a communitybased Ontology of Two-Component Systems (OTCS). Bacterial PhoPQ TCS in Escherichia coli is used as an example TCS for OTCS modeling in the study.