The effect of gestational age at the time of diagnosis on adverse pregnancy outcomes in women with COVID-19
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH(2021)
摘要
Objective We aimed to investigate the incidence of adverse pregnancy outcomes including preterm birth, preeclampsia (PE), and fetal growth restriction (FGR) in pregnant women with COVID-19 according to the gestational age. Methods This retrospective study included 167 pregnant women who were hospitalized with confirmed COVID-19. The patients were divided into three groups according to the time of diagnosis as follows: <12 weeks of gestation (first trimester, n = 10), 12-24 weeks of gestation (n = 28), and >24 weeks of gestation (n = 129). Medical records of the patients were reviewed retrospectively and adverse pregnancy outcomes were analyzed. Results A total of 49 (29.3%) patients had an active COVID-19 infection at the time of delivery, while 118 (70.7%) gave birth after the infection was cleared. Twenty-three patients had preterm birth and the gestational age was <34 weeks in only four of these patients. There was no significant difference in the preterm birth, PE, FGR, HELLP syndrome, and gestational diabetes mellitus among the three gestation groups (p = 0.271, 0.394, 0.403, 0.763, and 0.664, respectively). Four (2.39%) patients required intensive care unit stay. Maternal death was seen in only one (0.59%) patient. Conclusion Our study showed no significant correlation between the gestational age at the time of COVID-19 infection and the frequency of adverse pregnancy outcomes such as preterm birth, PE, FGR, and gestational diabetes mellitus. However, further studies are needed to draw a firm conclusion on this topic.
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关键词
COVID-19, gestational age, pregnancy outcome, trimester
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