Embryogenesis without CTCF in flies and vertebrates
NATURE STRUCTURAL & MOLECULAR BIOLOGY（2021）
摘要
CTCF is a conserved DNA- and RNA-binding protein with roles in genome folding and transcriptional regulation. Two recent studies investigated how CTCF knockout perturbs genome biology and derails embryogenesis in zebrafish and Drosophila melanogaster , revealing contrasting effects across species.
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关键词
Cell growth,Epigenetics,Life Sciences,general,Biochemistry,Protein Structure,Membrane Biology,Biological Microscopy
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