Renal sympathetic activation triggered by the rostral ventrolateral medulla is dependent of spinal cord AT1 receptors in Goldblatt hypertensive rats

Maycon I.O. Milanez, Erika E. Nishi,Rodrigo Mendes,Antônio A. Rocha,Cássia T. Bergamaschi,Ruy R. Campos

Peptides（2021）

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摘要

•Spinal AT1 receptors mediate renal sympathoexcitation caused by RVLM activation in 2K1C rats.•Spinal AT1 blockade reduces tachycardia and pressor effects evoked by RVLM activation in 2K1C rats.•Descending projections from RVLM control high sympathetic activity through spinal angiotensinergic actions in 2K1C rats.

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关键词

Rostral ventrolateral medulla,Spinal AT1 receptors,Renal sympathetic nerve,Splanchnic sympathetic nerve,Renovascular hypertension

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