Mitochondrial dysfunction in a mouse model of prodromal Parkinson’s disease: A metabolomic analysis

Masashi Ikuno,Hodaka Yamakado, Ikuko Amano,Yusuke Hatanaka,Norihito Uemura,Shu-Ichi Matsuzawa,Ryosuke Takahashi

Neuroscience Letters（2021）

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摘要

•Metabolomic analysis of the plasma from a mouse model of prodromal PD (p-PD).•Increased levels of isobutyrylcarnitine imply an abnormality in β-oxidation.•Systemic mitochondrial dysfunction may exist and contribute to the pathogenesis.

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关键词

Alpha-synuclein,Parkinson’s disease,Biomarker,Prodromal Parkinson’s disease,Mitochondria,Metabolome

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