Many heart transplant biopsies currently diagnosed as no rejection have mild molecular antibody-mediated rejection-related changes

Philip F Halloran,Katelynn Madill-Thomsen,Arezu Z Aliabadi-Zuckermann,Martin Cadeiras,Marisa G Crespo-Leiro,Eugene C Depasquale,Mario Deng,Johannes Gökler,Daniel H Kim,Jon Kobashigawa,Peter Macdonald,Luciano Potena,Keyur Shah,Josef Stehlik,Andreas Zuckermann

The Journal of Heart and Lung Transplantation（2022）

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摘要

Many heart transplants currently diagnosed as NR by histologic or molecular assessment have minor increases in ABMR-related and IFNG-inducible transcripts, associated with DSA positivity and mild histologic inflammation. These results suggest that low-level ABMR-related molecular stress may be operating in many more hearts than previously estimated. (ClinicalTrials.gov #NCT02670408).

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gene expression,biopsy,heart,transplantation,rejection

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