Urine Biomarkers for the Assessment of Acute Kidney Injury in Neonates with Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia

Jennifer Rumpel,Beverly J Spray,Valerie Y Chock,Megan J Kirkley,Cara L Slagle,Adam Frymoyer,Seo-Ho Cho,Katja M Gist,Richard Blaszak,Brenda Poindexter,Sherry E Courtney

The Journal of Pediatrics（2022）

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摘要

Urine NGAL, KIM-1, and IL-18 were elevated in neonates with HIE receiving TH who developed AKI. However, wide variability and unclear cut off levels make their clinical utility unclear.

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关键词

neutrophil gelatinase-associated lipocalin,kidney injury molecule-1,cystatin C,tissue inhibitor of metalloproteinases 2,insulin-like growth factor–binding protein 7,interleukin-18,acute kidney injury,hypoxic ischemic encephalopathy

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