Canadian ROS proto-oncogene 1 study (CROS) for multi-institutional implementation of ROS1 testing in non-small cell lung cancer

Lung Cancer（2021）

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摘要

•High quality ROS1 IHC assays have high clinical utility.•Adjusting readout can increase diagnostic accuracy in ROS1 IHC.•ROS1 IHC readout must be balanced with the analytical sensitivity of the assay.•A multi-institutional approach abets the validation of rare disease biomarker assays.

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关键词

Non-small cell lung cancer,ROS1,Immunohistochemistry,FISH,Biomarker testing,Quality assurance

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