Suppression of alveolar bone resorption by salubrinal in a mouse model of periodontal disease

Fumika Kimura,Ken Miyazawa,Kazunori Hamamura,Masako Tabuchi,Takuma Sato,Yuichiro Asano,Shunsuke Kako,Yuki Aoki,Yoshihiko Sugita,Hatsuhiko Maeda,Akifumi Togari,Shigemi Goto

Life Sciences（2021）

引用 8|浏览23

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摘要

•Salubrinal alleviates periodontitis in a mouse model of periodontal disease.•Salubrinal suppresses increase of osteoclasts caused by periodontitis.•Salubrinal attenuates decrease of osteoblasts caused by periodontitis.•Salubrinal suppresses the pro-inflammatory cytokine in periodontitis.

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关键词

Periodontitis,Salubrinal,Alveolar bone resorption,Pro-inflammatory cytokine,Stress to endoplasmic reticulum (ER)

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