Induction of P-glycoprotein expression and activity by prolactin in female rat liver

Lucila I. Ceré, María G. Sedlmeier, Mariana Semeniuk,Marcelo G. Luquita,Daniel Francés, María T. Ronco,Juan Pablo Rigalli,María L. Ruiz,Viviana A. Catania

Life Sciences（2021）

引用 3|浏览17

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摘要

•Hepatic P-glycoprotein is increased in middle lactation in rats.•Prolactin enhances hepatic P-glycoprotein in ovariectomized rats.•P-glycoprotein is transcriptionally regulated by prolactin.•Hyperprolactinemia leads to increased P-glycoprotein substrates biliary excretion.

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关键词

ABC transporter,Post-partum rat,Ovariectomized rat,Xenobiotic biliary excretion,Hyperprolactinemic state

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