Improving regorafenib's organ target precision via nano-assembly to change its delivery mode abolishes chemoresistance and liver metastasis of colorectal cancer

Jia Liu,Daan Fu,Kang Wang,Ye Yuan,Yan Deng,Lin Shi,Mingyi Li,Cheng Zhou,Xiaohuan Lu,Qiying Lv,Guobin Wang,Lin Wang,Zheng Wang

Journal of Colloid and Interface Science（2022）

引用 3|浏览38

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摘要

A regorafenib nanodrug is prepared by self-assembly using regorafenib and clinically approved indocyanine green, which sufficiently delivers regorafenib into colorectal tumor and liver metastasis, markedly enhances regorafenib’s therapeutic efficacy.

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关键词

Advanced colorectal cancer,Self-assembly,Regorafenib,Nanodrug,Drug delivery

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