Polyisoprenylated benzophenones and xanthones from the pericarp of Garcinia planchonii Pierre

Two new polyisoprenylated benzophenones, planchoniones A (1) and B (2), together with two known benzophenones (3, 4) and six known xanthones (5-10), were isolated from an ethyl acetate extract of the pericarp of Garcinia planchonii Pierre. Their structures were established using spectroscopic methods, mainly 1D and 2D NMR. The four benzophenones were evaluated for their cytotoxicity against MCF-7 human breast cancer cells, and showed almost no activity. Meanwhile, compounds 5-10 were investigated for their inhibitory effects towards alpha-glucosidase, and gamma-mangostin (5) exhibited the most remarkable effect with IC50 value of 15.3 +/- 0.9 mu M (compared with acarbose, IC50 = 224.9 +/- 3.6 mu M). [GARPHICS].