Nucleophilic Radiosynthesis Of Boron Neutron Capture Therapy-Oriented Pet Probe [F-18]Fbpa Using Aryldiboron Precursors

A reliable copper-mediated nucleophilic radiosynthesis of the PET imaging probe [F-18]FBPA was developed using novel aryldiboron precursors. The carrier-free [F-18]FBPA with radiochemical purity >99% was prepared routinely via the two-step synthesis with an automatic module and can be used for clinical PET imaging of tumours.