Tumor Treating Fields (TTFields) downregulate the Fanconi Anemia-BRCA pathway and increase the efficacy of chemotherapy in malignant pleural mesothelioma preclinical models

•TTFields are cytotoxic to pleural mesothelioma cells at optimal frequency of 150 kHz.•TTFields attenuate MPM tumor progression in murine models.•TTFields increase DNA damage in MPM, as previously seen in glioblastoma and NSCLC.•TTFields impair DNA damage repair in MPM, specifically the FA-BRCA pathway.•TTFields demonstrated synergism with cisplatin and additivity with pemetrexed.