Deficiency in WDFY4 reduces the number of CD8+ T cells via reactive oxygen species-induced apoptosis

Yan Li,Jiangxia Li,Qianqian Yuan,Xianli Bian,Feng Long,Ruonan Duan,Fei Gao,Shang Gao,Shijun Wei,Anran Wang,Ai Liu,Xi Li,Wenjie Sun,Qiji Liu

Molecular Immunology（2021）

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摘要

•WDFY4 modulates T cell fate via reactive oxygen species-induced apoptosis.•WDFY4 participates in apoptosis via the p53 and ERK pathways.•Wdfy4 influences the proliferation of CD8+ T cells.

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关键词

WDFY4,SLE,cDC1,CKO,DN,DP,SP,LN,ROS,Jurkat cell

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