HIV viral load suppression following intensive adherence counseling among people living with HIV on treatment at military-managed health facilities in Uganda

Bernard Kikaire, Michael Ssemanda,Alex Asiimwe, Miriam Nakanwagi, Twaha Rwegyema,Gloria Seruwagi,Stephen Lawoko,Evarlyne Asiimwe, Cassette Wamundu,Ambrose Musinguzi, Eric Lugada, Elizabeth Turesson, Marni Laverentz, Denis Bwayo

International Journal of Infectious Diseases(2021)

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摘要
Background: Uniformed service personnel have an increased risk of poor viral load suppression (VLS). This study was performed to evaluate the outcomes of interventions to improve VLS in the 28 military health facilities in Uganda.Methods: This operational research was conducted between October 2018 and September 2019, among people living with HIV (PLHIV) in the 28 health facilities managed by the military in Uganda. Patients with a viral load (VL) >1000 copies/ml received three sessions of intensive adherence counselling (IAC), 1 month apart, after which a repeat VL was done. The main outcome was the proportion with a suppressed VL following IAC.Results: Of the 965 participants included in this analysis, 592 (61.4%) were male and 367 (38.3%) were female. Average age was 35.5 ± 13.7 years, and 87.8% had at least one IAC session. At least 48.2% had a suppressed repeat VL. IAC increased the odds of VLS by 82% (P = 0.004), with adjusted OR of 1.56 (P = 0.054). An initial VL >10 000 copies/ml, being on antiretroviral therapy for at least 2 years, being male, and being <18 years of age were associated with repeat VL non-suppression.Conclusions: IAC marginally improved VL suppression. There is a need to improve IAC in military health facilities.
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关键词
HIV,Viral load,Intensive adherence counselling,Military,Low and middle-income countries
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