Infliximab Concentrations during Induction Are Predictive for Endoscopic Remission in Pediatric Patients with Inflammatory Bowel Disease under Combination Therapy

Karen van Hoeve,Nasim Sadat Seyed Tabib,Erwin Dreesen,Sophie Tops,Ilse Hoffman,Ann Gils,Marc Ferrante,Séverine Vermeire

The Journal of Pediatrics（2022）

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摘要

Higher IFX exposure during induction therapy in pediatric IBD patients is associated with significantly better endoscopic and deep remission rates at six months. Drug concentrations differentiate remitters from non-remitters from Week 4 post-induction onwards.

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关键词

children,inflammatory bowel disease,infliximab,outcome,proteomics,therapeutic drug monitoring

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