Exploring the interaction of Valsartan and Valsartan-Zn(ll) complex with DNA by spectroscopic and in silico methods

Kishor B. Kale,Mandakini A. Shinde,Rajendra H. Patil,Divya P. Ottoor

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy（2022）

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摘要

•Synthesis of valsartan zinc complex in 2:1 molar ratio.•Complexation of valsartan with zinc enhanced the anticancer activity against human lung cancer cell line.•Spectroscopic investigation to understand the binding mode with DNA.•Detailed in silico study to understand the mechanism of interaction and stability with DNA.

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关键词

Val,VZn,ROS,CD,MD,RMSD,SASA,ADME

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