PIK3CA mutations in plasma circulating tumor DNA predict survival and treatment outcomes in patients with advanced cancers

E I Dumbrava,S G Call,H J Huang, A L Stuckett, K Madwani, A Adat,D S Hong, S A Piha-Paul,V Subbiah,D D Karp, S Fu,A Naing,A M Tsimberidou,S L Moulder, K H Koenig,C H Barcenas,B K Kee,D R Fogelman,E S Kopetz, F Meric-Bernstam,F Janku

ESMO Open（2021）

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摘要

•Testing for PIK3CA mutations in ctDNA is concordant with testing of tumor tissue.•High PIK3CA-mutant abundance in ctDNA was associated with shorter survival.•Increasing PIK3CA-mutant abundance in serial blood samples was associated with shorter TTF.•Longitudinal monitoring of PIK3CA-mutant ctDNA tracked with cancer clinical course.

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关键词

PIK3CA,circulating tumor DNA,droplet digital PCR,cancer

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