Right ventricular and cyclic guanosine monophosphate signalling abnormalities in stages B and C of heart failure with preserved ejection fraction.

Thibault Petit,Guido Claessen,Mathias Claeys,Andre La Gerche,Piet Claus,Stefan Ghysels,Marion Delcroix,Agnieszka Ciarka,Walter Droogne,Johan Van Cleemput,Rik Willems,Jens-Uwe Voigt,Jan Bogaert,Stefan Janssens

ESC heart failure（2021）

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摘要

Exercise CMR identifies impaired RV-arterial coupling at an early stage of HFpEF. Circulating cGMP levels phenocopy the haemodynamic spectrum in HFpEF but fail to increase after phosphodiesterase type 5 inhibition, endorsing the need for alternative interventions to increase cGMP signalling in HFpEF.

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关键词

Cardiac magnetic resonance imaging,Exercise,Haemodynamics,Heart failure,Phosphodiesterase type 5 inhibitor

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