miRNA-223-3p modulates ibrutinib resistance through regulation of the CHUK/Nf-κb signaling pathway in mantle cell lymphoma

Jingjing Yuan,Qing Zhang,Shengsheng Wu,Suran Yan,Ran Zhao,Yajuan Sun,Xiaoxu Tian,Keshu Zhou

Experimental Hematology（2021）

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摘要

•miRNA-223-3p affects ibrutinib susceptibility in mantle cell lymphoma.•CHUK is targeted and negatively regulated by miRNA-223-3p.•The miRNA-223-3p/CHUK/NF-κB2 axis affects ibrutinib resistance in mantle cell.

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关键词

CHUK,NF-κB2 signaling pathway,drug resistance,mantle cell lymphoma,miRNA-223-3p

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