Intracellular Sphingosine-1-Phosphate Receptor 3 Contributes to Lung Tumor Cell Proliferation.

Michela Terlizzi,Chiara Colarusso,Giusy Ferraro,Maria Chiara Monti,Ilaria De Rosa,Pasquale Somma,Rosario Salvi,Aldo Pinto,Rosalinda Sorrentino

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2021）

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摘要

These results prove that the nuclear S1PR3/SPHK II axis is involved in lung tumor cell proliferation, highlighting a novel molecular mechanism which could provide differential therapeutic approaches especially in non-responsive lung cancer patients.

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关键词

Sphingosine-1-phosphate (S1P), S1P receptors, S1PR3, Smoking, Lung cancer

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