Correlation of immunohistochemical expression of HIF-1alpha and IDH1 with clinicopathological and therapeutic data of moroccan glioblastoma and survival analysis

•Brain tumours in adults, causing significant mortality and morbidity worldwide.•Glioblastomas are the aggressive primary intracranial tumours.•Glioblastomas are difficult to treat because of their inter-tumoral and intra-tumoral heterogeneity.•It is important to personalise care according to the molecular signature of glioblastoma for each patient.•The expression of HIF-1α is variable in glioblastoma, this expression is an indicator of intra-tumoral hypoxia.•A high expression of HIF-1α is associated with a poor prognosis in glioblastoma.