K2s2o8-Mediated Synthesis Of Highly Functionalized Pyrroles Via Oxidative Self-Dimerization Of N-Propargylamines

An efficient methodology has been developed for the synthesis of tetra- and pentasubstituted pyrroles via oxidative self-dimerization of N-propargylamines catalyzed by silver benzoate in the presence of K2S2O8 in good yields. The protocol provides a simple route for the synthesis of both tetra- and pentasubstituted pyrroles with two carbonyl groups in the side chain. The methodology can be extended toward the synthesis of pyrrolo-[3,4-d]pyridazine.