Role of growth hormone in hepatic and intestinal triglyceride-rich lipoprotein metabolism

Marie Maraninchi,Anastasia Calabrese,Juan-Patricio Nogueira,Frédéric Castinetti,Julien Mancini,Florian Mourre, Léa Piétri, Eric Bénamo,Frédérique Albarel,Isabelle Morange,Jeanine Dupont-Roussel,Alain Nicolay,Thierry Brue,Sophie Béliard,René Valéro

Journal of Clinical Lipidology（2021）

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摘要

•Short-term GH withdrawal improves fasting TRL metabolism in GH-deficient patients.•Short-term GH withdrawal has no effect on postprandial TRL metabolism.•Specific hepatic- but not intestinal-TRL metabolism improvement after GH withdrawal.•Hepatic-TRL metabolism improvement was associated to increased insulin sensitivity.•Hepatic-TRL metabolism improvement was associated to a decreased TRL-apoC-III level.

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关键词

GH-deficient patients,Growth hormone,Insulin resistance,Lipids,Triglyceride-rich lipoproteins

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