Impact of chronic kidney disease on long-term outcomes for coronary in-stent restenosis after drug-coated balloon angioplasty

•The outcomes of patients with chronic kidney disease (CKD) and coronary instent restenosis after drug-coated balloon (DCB) angioplasty remain unclear.•Patients with CKD after DCB angioplasty had a significantly higher risk of adverse cardiac events.•The majority of adverse cardiac events were driven by severe CKD or end-stage renal disease (ESRD) patients.•Different revascularization strategies may be considered for severe CKD or ESRD patients.