Development of a microneutralization assay for HSV-2

Melanie Horton,Michael Minnier,Scott Cosmi,Kara Cox,Jennifer Galli, Jessica Peters,Nicole Sullivan,Brian Squadroni,Aimin Tang,Arthur Fridman,Dai Wang,Zhifeng Chen,Kalpit Vora

Journal of Virological Methods（2021）

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摘要

•An HSV-2 MNA assay correlates with PRNT with and without the addition of complement.•MNA shows greater through-put and 90% reduction in assay time compared to the PRNT.•Human anti-HSV mAbs for virus detection show specificity for HSV gC and gE.•Binding of HSV-1 infected cells to the Fc portion of non-immune human IgG is shown.

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关键词

PRNT,HSV-2,MNA,HSV-1,gB,gD,gE,gC,ADCC,CPE,ELVIS,PBMC,NGS,RSV,S/N,CC,VC

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