Salsalate reduces atherosclerosis through AMPKβ1 in mice

Emily A Day,Rebecca J Ford,Brennan K Smith,Vanessa P Houde,Stephanie Stypa,Sonia Rehal,Šarka Lhoták,Bruce E Kemp,Bernardo L Trigatti,Geoff H Werstuck,Richard C Austin,Morgan D Fullerton,Gregory R Steinberg

Molecular Metabolism（2021）

引用 9|浏览8

暂无评分

摘要

•Salsalate (a dimer of salicylate) activates AMPK in macrophages and reduces atherosclerosis.•Salicylate-induced reductions in atherosclerosis are associated with reduced macrophage proliferation and serum cholesterol.•AMPK phosphorylation of HMG-CoA reductase is required for suppressing cholesterol synthesis and macrophage proliferation.

查看译文

关键词

Sterol synthesis,Lipogenesis,Macrophage,Proliferation,Salicylate,Aspirin

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要