Neuroprotective Effect of Alpha-asarone on the Rats Model of Cerebral Ischemia–Reperfusion Stroke via Ameliorating Glial Activation and Autophagy

Kun Zhang,Qi Liu,Lijun Luo,Xinqian Feng, Qinrui Hu,Xiangyu Fan,Shengjun Mao

Neuroscience（2021）

引用 17|浏览6

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摘要

•Alpha-asarone reduced infarct volume and improved neurological function.•Alpha-asarone treatment alleviated cell injury and apoptosis in vivo and in vitro.•Alpha-asarone decreased GFAP, Iba-1, and LC3II/LC3I expression.•Alpha-asarone is likely to be a promising agent for ischemic stroke.

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关键词

CIR,MCAO,TTC,H&E,GFAP,Iba-1,LC3,EDA,rtPA,CBF,OGD/R,ECA,ICA,TUNEL,DAPI

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