A monocyte/dendritic cell molecular signature of SARS-CoV-2-related multisystem inflammatory syndrome in children with severe myocarditis

Med（2021）

引用 33|浏览20

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摘要

Hyperinflammatory cytokines coupled with decrease in monocytes, cDCs, pDCs in MIS-CA molecular signature in monocytes can discriminate MIS-C with severe myocarditisIt consists of exacerbated TNF-α signaling linked with decreased NF-κB inhibitorsThis is observed in parallel to an absence of type I and type II IFN responses

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关键词

COVID-19,SARS-CoV-2,scRNA-seq,MIS-C,PIMS-TS,Kawasaki Disease,myocarditis,TNF-α and NF-κB signaling,lack of responses to type I and type II IFN secretion

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