Protective heterologous T cell immunity in COVID-19 induced by the trivalent MMR and Tdap vaccine antigens

Vijayashree Mysore,Xavier Cullere,Matthew L Settles,Xinge Ji,Michael W Kattan,Michaël Desjardins,Blythe Durbin-Johnson,Tal Gilboa,Lindsey R Baden,David R Walt, Andrew H Lichtman,Lara Jehi,Tanya N Mayadas

Med（2021）

引用 32|浏览10

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摘要

T cell responses to SARS-CoV-2, MMR, and Tdap vaccine proteins are highly correlatedSARS-CoV-2, MMR, and Tdap antigen-experienced T cells share identical TCRsT cells with shared TCRs have features of TEMRA, a memory anti-viral T cell subsetPrior MMR or Tdap vaccination correlates with reduced COVID-19 severity

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关键词

SARS-CoV-2,heterologous immunity,vaccines,antigens,antibody titers,memory T cells,TCR repertoire,transcriptome,antigen presenting cells,risk prediction

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