PD-L1 expression, EGFR and KRAS mutations and survival among stage III unresected non-small cell lung cancer patients: a Danish cohort study

Scientific reports(2021)

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摘要
Programmed cell death receptor ligand-1 (PD-L1) expression, KRAS ( KRASm ) and EGFR ( EGFRm ) mutations may influence non-small cell lung cancer (NSCLC) prognosis. We aimed to evaluate PD-L1 expression, KRASm, and EGFRm and survival among stage III unresected NSCLC patients. Using Danish registries, we collected data on stage III unresected NSCLC patients diagnosed 2001–2012 and paraffin-embedded tumor tissue from pathology archives. We assessed PD-L1 expression in tumors and tumor-infiltrating immune cells (ICs) by immunohistochemistry ( ≥ 1
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关键词
Biomarkers,Non-small-cell lung cancer,Oncology,Science,Humanities and Social Sciences,multidisciplinary
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