Clinical and molecular analysis of smoothened inhibitors in Sonic Hedgehog medulloblastoma.

Victor Pereira,Jacob Torrejon,Dulanjalee Kariyawasam,Pablo Berlanga,Léa Guerrini-Rousseau,Olivier Ayrault,Pascale Varlet,Arnault Tauziède-Espariat,Stéphanie Puget,Stéphanie Bolle,Kevin Beccaria,Thomas Blauwblomme,Laurence Brugières,Jacques Grill,Birgit Geoerger,Christelle Dufour,Samuel Abbou

Neuro-oncology advances（2021）

引用 5|浏览3

暂无评分

摘要

Targeting SMO in mutated is an interesting strategy for long-term responses. Combination of SMOi with chemotherapy or surgery and local radiotherapy is an appealing strategy to prevent early resistance and diminish SMOi exposure, especially in young patients. Inhibition of SHH pathway causes growth and development impairment but partial recovery of the growth velocity is possible.

查看译文

关键词

Sonic Hedgehog,growth plate fusion,medulloblastoma,smoothened inhibitor

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要