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Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency

Chun-Hui Zhang,Krasimir A. Spasov,Raquel A. Reilly,Klarissa Hollander,Elizabeth A. Stone,Joseph A. Ippolito,Maria-Elena Liosi,Maya G. Deshmukh,Julian Tirado-Rives,Shuo Zhang,Zhuobin Liang,Scott J. Miller,Farren Isaacs,Brett D. Lindenbach,Karen S. Anderson,William L. Jorgensen

ACS MEDICINAL CHEMISTRY LETTERS（2021）

Cited 44|Views35

Key words

SARS-CoV-2,protease inhibitors,lead optimization,COVID-19 drugs

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