An updated reappraisal of synapsins: structure, function and role in neurological and psychiatric disorders

•Three evolutionary conserved Synapsins genes have been identified.•Synapsins are involved in neuronal development and neurotransmitter release.•Synapsins exhibit distinctive localization, expression and post-translational modifications.•Synapsins alterations underlie the onset of multiple brain disorders.•Spotlight on the role of Synapsins in psychiatric and neurological disorders.