The microglial lysosomal system in Alzheimer’s disease: Guardian against proteinopathy

•Proteopathic inflammation arises in both neurodegenerative diseases and ageing.•Involvement of glial cells in Alzheimer-neurodegeneration is gaining momentum.•Microglia up- and downregulate risk genes that cluster in the endo-lysosomal system.•This is the concluding entity for both the degradative and inflammatory cascades.•As an enticing driver, this reinforces neuronal biochemical proteinopathy.