Effect of late-onset epilepsy on cognitive functioning in patients with small vessel disease

Marc Turon,Joan Jiménez-Balado,Laura Abraira,Elena Fonseca,Manuel Quintana,Manuel Toledo,Pilar Delgado,Olga Maisterra,Xavier Salas-Puig,José Álvarez-Sabín,Estevo Santamarina

Epilepsy & Behavior（2021）

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摘要

•Patients with cSVD-LOE showed poorer cognitive performance compared with patients with cSVD.•Cognitive profile in cSVD-LOE is different from that typically observed in cSVD.•Epilepsy was the major contributor to the decrease in verbal memory.•Seizure localization and vascular burden were not related with cognitive performance.•Epilepsy could be an early sign of incipient neurodegenerative disease in these patients.

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关键词

Late-onset epilepsy,Small-vessel disease,Vascular burden,Cognitive impairment,Dementia,Memory

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