Analysis of the Gadolinium retention in the Experimental Autoimmune Encephalomyelitis (EAE) murine model of Multiple Sclerosis

Chiara Furlan,Francesca Montarolo,Enza Di Gregorio,Roberta Parolisi,Sandra Atlante,Annalisa Buffo,Antonio Bertolotto,Silvio Aime,Eliana Gianolio

Journal of Trace Elements in Medicine and Biology（2021）

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摘要

•A damaged BBB leads to the detection of amounts of Gd significantly higher than in healthy mice.•In the spinal cord of EAE mice, a preferential but transient retention of Gd is observed.•Ongoing inflammation in EAE and SHAM mice facilitates the retention of Gd in cerebrum and cerebellum.

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MS,GBCAs,EAE,ICP-MS,TEM,BBB,CE-MRI,EES,PRAC,EMA,FDA,DN,IFA,MOG,LOQ,RARE,FOV,MSME,BCCAo

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