Triptolide decreases rheumatoid arthritis fibroblast-like synoviocyte proliferation, invasion, inflammation and presents a therapeutic effect in collagen-induced arthritis rats via inactivating lncRNA RP11-83J16.1 mediated URI1 and β-catenin signaling

•TP inhibits RA-FLS viability and lncRNA RP11-83J16.1 in a dose-dependent manner.•TP inhibits RA-FLS proliferation, invasion, inflammatory level, URI1 signaling.•LncRNA RP11-83J16.1 weakens the effects of triptolide on RA-FLS cell behaviors.•TP decreases CIA model arthritis score, synovial tissue inflammation infiltration.