Distinct difference in tumor-infiltrating immune cells between Wilms' tumor gene 1 peptide vaccine and anti-programmed cell death-1 antibody therapies.

Chisato Yokota,Jun Nakata,Koji Takano,Hiroko Nakajima,Hiromu Hayashibara,Hikaru Minagawa,Yasuyoshi Chiba,Ryuichi Hirayama,Noriyuki Kijima,Manabu Kinoshita,Yoshiko Hashii,Akihiro Tsuboi,Yoshihiro Oka,Yusuke Oji,Atsushi Kumanogoh,Haruo Sugiyama,Naoki Kagawa,Haruhiko Kishima

Neuro-oncology advances（2021）

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摘要

Our results clearly demonstrated that WT1 peptide vaccine and anti-PD-1 antibody therapies worked in the different steps of cancer-immunity cycle and that the combination of the two therapies could work synergistically against glioblastoma.

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PD-1,WT1,cancer vaccine,combination therapy,glioblastoma,immunotherapy

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