Dosimetric evaluation of ovaries and pelvic bones associated with clinical outcomes in patients receiving total body irradiation with ovarian shielding

Keiko Akahane,Katsuyuki Shirai,Masaru Wakatsuki,Masato Suzuki,Shogo Hatanaka,Yuta Takahashi,Masahiro Kawahara,Kazunari Ogawa,Satoru Takahashi,Noriko Oyama-Manabe,Masahiro Ashizawa,Shun-Ichi Kimura,Shinichi Kako,Yoshinobu Kanda

Journal of Radiation Research（2021）

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摘要

Total body irradiation (TBI) with ovarian shielding is expected to preserve fertility among hematopoietic stem cell transplant (HSCT) patients with myeloablative TBI-based regimens. However, the radiation dose to the ovaries that preserves ovarian function in TBI remains poorly understood. Furthermore, it is uncertain whether the dose to the shielded organs is associated with relapse risk. Here, w...

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关键词

relapse,ovarian shielding,fertility,total body irradiation (TBI)

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