Incidence and risk factors of cancer in individuals with cystic fibrosis in the UK; a case-control study

•What is the key question? Which are the most common cancers in the UK cystic fibrosis population and what factors are associated with the incidence of all cancers and in particular gastrointestinal malignancies?•What is the bottom line? The types of cancer in people with CF are varied but reflect those found in the general population. Any cancer and particularly GI cancer appear to be peaking at a younger age, while CFRD is confirmed as a risk factor alongside transplantation.•Why read on? This is the largest study conducted in the UK CF population exploring patterns of cancer incidence and factors associated with it. We observed a high incidence of GI cancers, skin and breast cancers compared to other cancer types. Screening for gastrointestinal cancers could benefit patients at higher risk.