Cd36 Pumps Fat To Defang Killer T Cells In Tumors

Manikandan Subramanian,Federica M Marelli-Berg

CELL METABOLISM（2021）

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摘要

The tumor microenvironment is immunosuppressive. Here we preview two recent studies from Ma et al. (2021) in Cell Metabolism and Xu et al. (2021) in Immunity that describe a key role of T cell-expressed CD36 in enhancing lipid uptake and mediating lipid peroxidation that ultimately leads to CD8+ T cell dysfunction, ferroptosis, and reduced anti-tumor function.

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