The Lipopolysaccharide-Sensing Caspase(s)-4/11 Are Activated in Cirrhosis and Are Causally Associated With Progression to Multi-Organ Injury.

Ugo Soffientini,Nigel Beaton,Sukriti Baweja,Emmanuel Weiss,Chhagan Bihari,Abeba Habtesion,Vishal Patel,Valerie Paradis,Archana Sharma,Tu Vinh Luong,Andrew Hall,Aida Nadar,Shiv Sarin,Shilpa Chokshi,Roger Williams,Benedicte Py,Richard Moreau,Rajiv Jalan,Gautam Mehta

Frontiers in cell and developmental biology（2021）

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摘要

These data demonstrate for the first time a causal relationship between LPS-mediated activation of caspase(s)-4/11 and development of hepatic and extra-hepatic injury in cirrhosis.

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关键词

caspase,cirrhosis,dysbiosis,endotoxin,lipopolysaccharide,liver failure,pyroptosis

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