The impact of isolated local recurrence on long-term outcome in early-breast cancer patients after breast-conserving therapy

•Long-term outcome after isolated local recurrence (ILR) in early-breast cancer.•Data pooled from EORTC ‘boost-no boost’ (N = 5569) and IM-MS (N = 4004) trials.•In the case of ILR, 12% occurred in the first 2 years while 30% only after 10 years.•10-year breast cancer mortality rate after ILR was higher in the case of early ILR.•Multistate model predicted outcome based on patient data, FU length, the timing of ILR.