Thrombospondin 1 and 2 along with PEDF inhibit angiogenesis and promote lymphangiogenesis in intrahepatic cholangiocarcinoma

Guido Carpino,Vincenzo Cardinale,Alessandra Di Giamberardino,Diletta Overi,Samantha Donsante,Tania Colasanti,Gaia Amato,Gianluca Mennini,Matteo Franchitto,Fabrizio Conti,Massimo Rossi,Mara Riminucci,Eugenio Gaudio,Domenico Alvaro,Carmine Mancone

Journal of Hepatology（2021）

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摘要

•iCCA microenvironment shows hypovascularity and a rich lymphatic system.•Identification of angio-inhibitory proteins in the iCCA extracellular fluid.•THBS1, THBS2 and PEDF induce hypovascularity and lymphangiogenesis in vivo.•Targeting THBS1, THBS2 and PEDF reduces in vivo tumor-associated lymphangiogenesis.•This study identifies new molecular targets to counteract iCCA invasiveness.

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关键词

Tumor microenvironment,extracellular matrix,proteomics,angiogenesis,lymphangiogenesis

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